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KMID : 0605620150220040149
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Journal of Korean Society of Biological Psychiatry
2015 Volume.22 No. 4 p.149 ~ p.154
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Other N-Methyl-D-Aspartate (NMDA) Receptor Antagonists with a Rapid Onsetof Action and Less Side Effect in the Treatment of Depression
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최범성:Choi Bum-Sung
이화영:Lee Hwa-Young
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Abstract
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Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. Many prescribed antidepressants modulate monoamine neurotransmitters including serotonin, norepinephrine and dopamine. There has been greater focus on the major excitatory neurotransmitter in the human brain, glutamate, in the pathophysiology and treatment of major depressive disorder (MDD). Recently, ketamine, an N-methyl-D-aspartate receptor antagonist, has received attention and has been investigated for clinical trials and neurobiological studies. In this article, we will review the clinical evidence for glutamatergic dysfunction in MDD, the progress with ketamine as a rapidly acting antidepressant, and other N-methyl-D-aspartate receptor antagonist for treatment-resistant depression.
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KEYWORD
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Major depressive disorder, Glutamate, NMDA receptor antagonist, Ketamine
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